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Medically significant venom because it can cause issues with breathing, may affect blood pressure, cause neurological issues, heart palpitations, dizziness, and etc. Now if you are a healthy individual it may not matter much. But if you are taking medications for lets say, heart issues or blood...
New world tarantulas have urticating hairs. They kick those urticating hairs in their abdomen as a way to defend themselves and ward of potential predators.
If you can, take the crickets out. It is not advisable to leave live prey in as it can hurt a molting T. I usually take the preys out if the T is not interested.